For research use only. Not for therapeutic Use.
Potent MCT1 inhibitor (IC<sub>50</sub> = 0.5 nM); blocks proliferation of Raji lymphoma cells <em>in vitro</em>. Also inhibits lactate uptake in breast cancer cells <em>in vitro</em>.
| Catalog Number | I011193 |
| CAS Number | 227321-12-2 |
| Synonyms | 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one |
| Molecular Formula | C25H29N3O2S |
| Purity | ≥95% |
| Target | Monocarboxylate Transporter |
| Solubility | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| Storage | Store at +4C |
| IUPAC Name | 5-(3-hydroxypropylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)pyrrolo[3,4-d]pyridazin-4-one |
| InChI | InChI=1S/C25H29N3O2S/c1-17(2)14-22-21-16-28(15-19-10-6-9-18-8-4-5-11-20(18)19)25(31-13-7-12-29)23(21)24(30)27(3)26-22/h4-6,8-11,16-17,29H,7,12-15H2,1-3H3 |
| InChIKey | VDAVMXLEMHVXOG-UHFFFAOYSA-N |
| SMILES | CC(C)CC1=NN(C(=O)C2=C(N(C=C12)CC3=CC=CC4=CC=CC=C43)SCCCO)C |
