SR 142948 dihydrochloride

• CAT Number: I041435
• Molecular Formula: C39H53Cl2N5O6
• Molecular Weight: 758.77
• Purity: ≥95%
• Synonyms: 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methylcarbamoyl]-2-propan-2-ylphenyl]pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid;dihydrochloride
• InChI: InChI=1S/C39H51N5O6.2ClH/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24;;/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48);2*1H
• InChIKey: AQJKZKHTPLUIAD-UHFFFAOYSA-N
• SMILES: CC(C)C1=C(C=CC(=C1)C(=O)N(C)CCCN(C)C)N2C(=CC(=N2)C(=O)NC3(C4CC5CC(C4)CC3C5)C(=O)O)C6=C(C=CC=C6OC)OC.Cl.Cl

SR 142948 dihydrochloride（Cat No.:I041435）is a potent and selective non-peptide antagonist of the corticotropin-releasing factor (CRF) receptor 1. It is primarily used in research related to neurobiology and stress response, where CRF plays a key role in regulating the body’s reaction to stress and anxiety. SR 142948 dihydrochloride is valuable in preclinical studies aimed at understanding the mechanisms of stress-related disorders such as anxiety and depression. It also holds potential for developing therapeutic agents to treat these conditions. The compound’s high selectivity for CRF receptor 1 makes it a crucial tool in pharmacological investigations.