For research use only. Not for therapeutic Use.
SR-18292（Cat No.:I009579）is a compound that acts as an inhibitor of PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1 alpha). By inhibiting PGC-1α, SR-18292 demonstrates several beneficial effects in dietary and genetic mouse models of type 2 diabetes (T2D). It reduces blood glucose levels, enhances hepatic insulin sensitivity, and improves glucose homeostasis. These findings suggest that targeting PGC-1α with SR-18292 holds potential as a therapeutic approach for managing T2D and addressing insulin resistance-related metabolic abnormalities.
| Catalog Number | I009579 |
| CAS Number | 2095432-55-4 |
| Synonyms | SR-18292; SR 18292; SR18292.;1-((1H-indol-4-yl)oxy)-3-(tert-butyl(4-methylbenzyl)amino)propan-2-ol |
| Molecular Formula | C23H30N2O2 |
| Purity | ≥95% |
| Target | PGC-1α inhibitor |
| Solubility | Soluble in DMSO |
| Storage | 2-8°C |
| IUPAC Name | 1-[tert-butyl-[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)propan-2-ol |
| InChI | InChI=1S/C23H30N2O2/c1-17-8-10-18(11-9-17)14-25(23(2,3)4)15-19(26)16-27-22-7-5-6-21-20(22)12-13-24-21/h5-13,19,24,26H,14-16H2,1-4H3 |
| InChIKey | BNRANURXPKRRKP-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)CN(CC(COC2=CC=CC3=C2C=CN3)O)C(C)(C)C |
| Reference | </br>1: Sharabi K, Lin H, Tavares CD, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 Mar 23;169(1):148-160.e15. doi: 10.1016/j.cell.2017.03.001. PubMed PMID: 28340340. |
