For research use only. Not for therapeutic Use.
SR-3576 is a highly potent and selective JNK3 inhibitor with an IC50 of 7 nM[1].
| Catalog Number | I011085 |
| CAS Number | 1164153-22-3 |
| Synonyms | 3-[4-[(3-methylphenyl)carbamoylamino]pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide |
| Molecular Formula | C27H27N5O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34) |
| InChIKey | MTFAYLZZDJGFGV-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC=C1)NC(=O)NC2=CN(N=C2)C3=CC=CC(=C3)C(=O)NC4=CC(=C(C(=C4)OC)OC)OC |
| Reference | [1]. Kamenecka T, et al. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284(19):12853-61. |
