For research use only. Not for therapeutic Use.
SR-3677（Cat No.:I000336）is a selective inhibitor of Rho-associated protein kinase (ROCK) II, an enzyme involved in regulating cytoskeletal dynamics, cell motility, and vascular tone. By inhibiting ROCK II, SR-3677 reduces smooth muscle contraction and cell migration, making it a valuable tool for studying cardiovascular diseases, neurological disorders, and cancer metastasis. It has shown promise in preclinical models of hypertension, glaucoma, and fibrotic diseases, where dysregulated ROCK activity plays a role. SR-3677’s selectivity for ROCK II over other isoforms minimizes off-target effects, enhancing its potential therapeutic applications.
| Catalog Number | I000336 |
| CAS Number | 1072959-67-1 |
| Synonyms | N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide |
| Molecular Formula | C22H24N4O4 |
| Purity | ≥95% |
| Target | ROCK |
| Solubility | DMSO: ≥ 43 mg/mL |
| Storage | Store at -20C |
| IC50 | 3 nM |
| IUPAC Name | N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide |
| InChI | InChI=1S/C22H24N4O4/c1-26(2)9-10-28-20-11-15(16-12-23-24-13-16)7-8-17(20)25-22(27)21-14-29-18-5-3-4-6-19(18)30-21/h3-8,11-13,21H,9-10,14H2,1-2H3,(H,23,24)(H,25,27) |
| InChIKey | OQWZIAVXCYIZNN-UHFFFAOYSA-N |
| SMILES | CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)C3COC4=CC=CC=C4O3 |
| Reference | <p style=/line-height:25px/> <br>[1]. Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5. |
