For research use only. Not for therapeutic Use.
An orally active, non-peptide, high affinity neurotensin (NT1 or NTS1) receptor antagonist.
KEYWORDS: SR 48692 | supplier | NT1 antagonist | Meclinertant | SR48692 | CAS [146362-70-1] | Neurotensin | NT | NTS1 | cocaine sensitization | nitric oxide | diuretic action
| Catalog Number | R033805 |
| CAS Number | 146362-70-1 |
| Molecular Formula | C32H31ClN4O5 |
| Purity | ≥95% |
| IUPAC Name | 2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid |
| InChI | InChI=1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40) |
| SMILES | COC1=C(C(=CC=C1)OC)C2=CC(=NN2C3=C4C=CC(=CC4=NC=C3)Cl)C(=O)NC5(C6CC7CC(C6)CC5C7)C(=O)O |
| Reference | Horger et al. Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine Sensitization.Neuropsychopharmacology 1994, 11, 215-222.
Croci et al. Negative modulation of nitric oxide production by neurotensin as a putative mechanism of the diuretic action of SR 48692 in rats. Br. J. Pharmacol. 1997, 120, 1312–1318. |
