SR 8278-d3

• CAT Number: R024917
• CAS Number: NA
• Molecular Formula: C₁₈H₁₆D₃NO₃S₂
• Molecular Weight: 364.50
• Purity: ≥95%
• Synonyms: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic Acid Ethyl Ester-d3
• Storage: Room temperature
• IUPAC Name: ethyl 2-[5-(trideuteriomethylsulfanyl)thiophene-2-carbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylate
• InChI: InChI=1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3/i2D3
• InChIKey: UIEBLUZPSFAFOC-BMSJAHLVSA-N
• SMILES: [2H]C([2H])([2H])SC1=CC=C(S1)C(=O)N2CC3=CC=CC=C3CC2C(=O)OCC

SR 8278-d3（Cat No.:R024917） is a deuterated variant of SR 8278, a synthetic compound known for its role as a REV-ERB antagonist, which is significant in circadian rhythm research. This compound, with three deuterium atoms, offers enhanced metabolic stability, making it highly valuable for in vivo pharmacokinetic studies. It helps in understanding the pharmacodynamics and therapeutic potential of REV-ERB modulation in disorders related to sleep, metabolism, and inflammation. SR 8278-d3 is crucial for researchers studying the mechanism of action and possible therapeutic applications of circadian rhythm modulators.