SR1001

• CAT Number: I001279
• CAS Number: 1335106-03-0
• Molecular Formula: C15H13F6N3O4S2
• Molecular Weight: 477.39
• Purity: ≥95%
• Synonyms: (Z)-N-(5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)sulfamoyl)-4-methylthiazol-2-yl)acetimidic acid
• Target: Nuclear Receptors
• Solubility: DMSO: ≥ 39 mg/mL
• Storage: Store at +4C
• IUPAC Name: N-[5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]sulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide
• InChI: InChI=1S/C15H13F6N3O4S2/c1-7-11(29-12(22-7)23-8(2)25)30(27,28)24-10-5-3-9(4-6-10)13(26,14(16,17)18)15(19,20)21/h3-6,24,26H,1-2H3,(H,22,23,25)
• InChIKey: OZBSSKGBKHOLGA-UHFFFAOYSA-N
• SMILES: CC1=C(SC(=N1)NC(=O)C)S(=O)(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O

SR1001（Cat No.:I001279）is a selective modulator of nuclear receptors RORα and RORγ, key regulators of immune function and metabolism. By inhibiting these receptors, SR1001 effectively reduces the production of pro-inflammatory cytokines and Th17 cell differentiation, making it a promising compound for treating autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Additionally, SR1001 has been explored for its potential role in metabolic disorders due to its influence on circadian rhythms and lipid metabolism. Its ability to target specific immune pathways makes SR1001 a valuable tool in immunology and metabolic research.

Reference

[1]. Solt LA, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 2011 Apr 28;472(7344):491-4.
[2]. Crumbley C, et al. Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα). PLoS One. 2012;7(4):e33804.