For research use only. Not for therapeutic Use.
SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma[1].
SR2640 inhibits the LTD 4-induced contractions of guinea-pig ileum in a concentration-dependent manner, with an IC50 of 3 nM[1].
SR2640 (1 mg/kg; IV; single dosage) specifically prevents the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4[1].
| Catalog Number | I010463 |
| CAS Number | 146662-42-2 |
| Synonyms | 2-[3-(quinolin-2-ylmethoxy)anilino]benzoic acid;hydrochloride |
| Molecular Formula | C23H19ClN2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H18N2O3.ClH/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18;/h1-14,24H,15H2,(H,26,27);1H |
| InChIKey | KDSYWFCTUKABKE-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C=CC(=N2)COC3=CC=CC(=C3)NC4=CC=CC=C4C(=O)O.Cl |
| Reference | [1]. Ahnfelt-Rønne I, Kirstein D, Kaergaard-Nielsen C. A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur J Pharmacol. 1988;155(1-2):117-128. |
