SR9011

• CAT Number: I001463
• CAS Number: 1379686-29-9
• Molecular Formula: C23H31ClN4O3S
• Molecular Weight: 479
• Purity: ≥95%
• Synonyms: 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
• Target: Nuclear Receptors
• Solubility: DMSO: ≥ 35 mg/mL
• Storage: Store at -20°C
• IC50: 790 nM (Rev-ErbBα), 560 nM (Rev-ErbBβ)
• InChIKey: PPUYOYQTTWJTIU-UHFFFAOYSA-N

SR9011(CAT: I001463) functions as an agonist of REV-ERB, a nuclear receptor that plays a critical role in regulating the circadian rhythm and various metabolic processes. Through its interaction with REV-ERB, SR9011 exerts regulatory control over genes involved in energy metabolism, lipid homeostasis, and glucose utilization. By modulating the activity of REV-ERB, SR9011 demonstrates the potential to influence the body’s internal clock and metabolic functions.

Reference

[1]. Solt LA, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012 Mar 29;485(7396):62-68.