For research use only. Not for therapeutic Use.
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].
SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1].
SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2].
| Catalog Number | I046366 |
| CAS Number | 2070014-88-7 |
| Synonyms | 1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea;hydrochloride |
| Molecular Formula | C20H32ClN3O |
| Purity | ≥95% |
| InChI | InChI=1S/C20H31N3O.ClH/c24-20(22-19-9-5-2-6-10-19)23(15-17-7-3-1-4-8-17)16-18-11-13-21-14-12-18;/h1,3-4,7-8,18-19,21H,2,5-6,9-16H2,(H,22,24);1H |
| InChIKey | GPNMJVSGNMDOJN-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)NC(=O)N(CC2CCNCC2)CC3=CC=CC=C3.Cl |
| Reference | [1]. Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978. [2]. Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499. |
