SRI 31215 TFA

• CAT Number: I019201
• CAS Number: 1832686-44-8
• Molecular Formula: C₂₇H₃₄F₃N₅O₃
• Molecular Weight: 533.59
• Purity: ≥95%
• Target: c-Met/HGFR

SRI 31215 (TFA) (Cat.No:I019201), a triplex inhibitor of matriptase, hepsin and hepatocyte growth factor activator (HGFA) with IC50s of 0.69 μM, 0.65 μM, 0.3 μM, blocks pro-HGF activation and thus mimics the activity of HAI-1/2.

Reference

[1]. Owusu BY, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506.