For research use only. Not for therapeutic Use.
SRI 37892(CAT: I036635) is a small-molecule inhibitor targeting Frizzled protein 7 (Fzd7), a key receptor in the Wnt signaling pathway. With an IC50 of 2 μM, SRI 37892 effectively inhibits cancer cell proliferation by blocking Wnt/Fzd7-mediated signaling. This disruption of Wnt signaling, which is often dysregulated in various cancers, positions SRI 37892 as a valuable tool in cancer biology research. It is particularly useful for investigating the role of Fzd7 in tumor progression and for the development of targeted anticancer therapies. SRI 37892 is suitable for in vitro and preclinical studies focused on Wnt pathway modulation.
| CAS Number | 1030769-75-5 |
| Synonyms | 4-(benzimidazol-1-yl)-N-[4-(2-oxo-3,4-dihydro-1H-quinolin-6-yl)-1,3-thiazol-2-yl]benzamide |
| Molecular Formula | C26H19N5O2S |
| Purity | ≥95% |
| IUPAC Name | 4-(benzimidazol-1-yl)-N-[4-(2-oxo-3,4-dihydro-1H-quinolin-6-yl)-1,3-thiazol-2-yl]benzamide |
| InChI | InChI=1S/C26H19N5O2S/c32-24-12-8-17-13-18(7-11-20(17)28-24)22-14-34-26(29-22)30-25(33)16-5-9-19(10-6-16)31-15-27-21-3-1-2-4-23(21)31/h1-7,9-11,13-15H,8,12H2,(H,28,32)(H,29,30,33) |
| InChIKey | DXSMYUKZPWJQFM-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC2=C1C=C(C=C2)C3=CSC(=N3)NC(=O)C4=CC=C(C=C4)N5C=NC6=CC=CC=C65 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
