For research use only. Not for therapeutic Use.
SRI-43265 (Cat No.: I040010), also known as compound 40, is a small-molecule inhibitor targeting the dimerization of human antigen R (HuR) protein, an RNA-binding protein involved in mRNA stability and translation. HuR multimers have been implicated in the pathogenesis of cancer and inflammatory diseases. By disrupting HuR dimerization, SRI-43265 may interfere with HuR-mediated post-transcriptional regulation, offering potential therapeutic applications in oncology and inflammatory conditions.
| CAS Number | 2727872-88-8 |
| Synonyms | 3-(1H-indazol-5-yl)-N-methyl-N-(oxan-4-yl)imidazo[1,2-b]pyridazin-6-amine |
| Molecular Formula | C19H20N6O |
| Purity | ≥95% |
| InChI | InChI=1S/C19H20N6O/c1-24(15-6-8-26-9-7-15)19-5-4-18-20-12-17(25(18)23-19)13-2-3-16-14(10-13)11-21-22-16/h2-5,10-12,15H,6-9H2,1H3,(H,21,22) |
| InChIKey | UYAQXKNZGMAYGA-UHFFFAOYSA-N |
| SMILES | CN(C1CCOCC1)C2=NN3C(=NC=C3C4=CC5=C(C=C4)NN=C5)C=C2 |
| Reference | [1]. Preparation of imidazopyridazinamines as RNA-binding protein multimerization inhibitors and methods of use thereof. World Intellectual Property Organization, WO2021216757 A1 2021-10-28. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
