For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia[1].
| Catalog Number | I043438 |
| CAS Number | 2347517-69-3 |
| Synonyms | N-[1-benzofuran-2-yl(pyridin-3-yl)methyl]-N’-[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]butanediamide |
| Molecular Formula | C41H46N6O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C41H46N6O6S/c1-24(26-12-14-27(15-13-26)37-25(2)43-23-54-37)44-39(51)31-20-30(48)22-47(31)40(52)38(41(3,4)5)46-35(50)17-16-34(49)45-36(29-10-8-18-42-21-29)33-19-28-9-6-7-11-32(28)53-33/h6-15,18-19,21,23-24,30-31,36,38,48H,16-17,20,22H2,1-5H3,(H,44,51)(H,45,49)(H,46,50)/t24-,30+,31-,36?,38+/m0/s1 |
| InChIKey | NQNKFJCCIWJMPC-LVNYTEOHSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCC(=O)NC(C4=CN=CC=C4)C5=CC6=CC=CC=C6O5)O |
| Reference | [1]. Method for dual-target construction of protac, and use thereof. WO2020119192A1. |
