(S,R,S)-AHPC-C3-NH2

• CAT Number: I016947
• CAS Number: 2361119-88-0
• Molecular Formula: C₂₆H₃₇N₅O₄S
• Molecular Weight: 515.67
• Purity: ≥95%
• Target: E3 Ligase Ligand-Linker Conjugates
• IUPAC Name: (2S,4R)-1-[(2S)-2-(4-aminobutanoylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C26H37N5O4S/c1-16-22(36-15-29-16)18-9-7-17(8-10-18)13-28-24(34)20-12-19(32)14-31(20)25(35)23(26(2,3)4)30-21(33)6-5-11-27/h7-10,15,19-20,23,32H,5-6,11-14,27H2,1-4H3,(H,28,34)(H,30,33)/t19-,20+,23-/m1/s1
• InChIKey: BTWJXNBKKYWEHA-ZRCGQRJVSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCN)O

(S,R,S)-AHPC-C3-NH2(CAT: I016947) is a potent and selective ligand for cereblon (CRBN), a key component of the E3 ubiquitin ligase complex, widely utilized in PROTAC (proteolysis-targeting chimera) research. It serves as a building block for designing bifunctional molecules that target specific proteins for ubiquitination and subsequent degradation. This compound is particularly valuable for studying targeted protein degradation pathways, offering insights into therapeutic strategies for conditions such as cancer, neurodegenerative disorders, and other proteinopathy-related diseases. With its high specificity and adaptability, (S,R,S)-AHPC-C3-NH2 is an essential tool for advancing drug discovery and the development of next-generation therapeutics.