(S,R,S)-AHPC-CO-C9-NH2 hydrochloride

• CAT Number: I040014
• CAS Number: 2376139-50-1
• Molecular Formula: C32H50ClN5O4S
• Molecular Weight: 636.29
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-(10-aminodecanoylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;hydrochloride
• InChI: InChI=1S/C32H49N5O4S.ClH/c1-22-28(42-21-35-22)24-15-13-23(14-16-24)19-34-30(40)26-18-25(38)20-37(26)31(41)29(32(2,3)4)36-27(39)12-10-8-6-5-7-9-11-17-33;/h13-16,21,25-26,29,38H,5-12,17-20,33H2,1-4H3,(H,34,40)(H,36,39);1H/t25-,26+,29-;/m1./s1
• InChIKey: CXWPAWUFEPOOLS-DDLJGEAHSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCCCCCN)O.Cl

(S,R,S)-AHPC-CO-C9-NH₂ Hydrochloride (Cat No.: I040014) is a synthetic ligand used in targeted protein degradation research, particularly as a key component in proteolysis-targeting chimeras (PROTACs). It functions as a cereblon (CRBN) E3 ligase ligand, facilitating ubiquitination and subsequent degradation of target proteins. This compound is widely applied in cancer and neurodegenerative disease studies to explore novel therapeutic strategies. The hydrochloride salt enhances solubility and stability for in vitro and in vivo applications, making it valuable in drug discovery and targeted protein degradation research.