(S,R,S)-AHPC

• CAT Number: I018714
• CAS Number: 1448297-52-6
• Molecular Formula: C₂₂H₃₀N₄O₃S
• Molecular Weight: 430.56
• Purity: ≥95%
• Target: Ligands for E3 Ligase

(S,R,S)-AHPC (CAT: I018714), also known as VH032-NH2, is a ligand derived from VH032, which is a small molecule that specifically binds to the von Hippel-Lindau (VHL) protein. VHL is an E3 ubiquitin ligase that plays a crucial role in the ubiquitin-proteasome pathway and regulates the stability of various target proteins, including the hypoxia-inducible factors (HIFs). (S,R,S)-AHPC is designed to recruit the VHL protein and promote the degradation of specific target proteins.

Reference

[1]. Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.