For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTAC[1]. (S,R,S)-AHPC-Me-C6-NH2 (Compound SI-9) contains VHL ligand 2 (HY-112078)[2].
| Catalog Number | I042655 |
| CAS Number | 2411422-49-4 |
| Synonyms | (2S,4R)-1-[(2S)-2-(7-aminoheptanoylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide |
| Molecular Formula | C30H45N5O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C30H45N5O4S/c1-19(21-11-13-22(14-12-21)26-20(2)32-18-40-26)33-28(38)24-16-23(36)17-35(24)29(39)27(30(3,4)5)34-25(37)10-8-6-7-9-15-31/h11-14,18-19,23-24,27,36H,6-10,15-17,31H2,1-5H3,(H,33,38)(H,34,37)/t19-,23+,24-,27+/m0/s1 |
| InChIKey | UGZLQBJANUBKTH-BOALBMDWSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCCN)O |
| Reference | [1]. Haibing Zhou, et al. Oseltamivir PROTAC compound, preparation method thereof and application thereof in anti-influenza virus drugs. Patent CN112592331A. [2]. Bondeson DP, et al. Systematic profiling of conditional degron tag technologies for target validation studies. Nat Commun. 2022 Sep 20;13(1):5495. |
