(S,R,S)-AHPC-propargyl

• CAT Number: I017618
• CAS Number: 2098799-78-9
• Molecular Formula: C₂₇H₃₄N₄O₅S
• Molecular Weight: 526.65
• Purity: ≥95%
• Target: Ligands for E3 Ligase
• IUPAC Name: (2S,4R)-1-[(2S)-3,3-dimethyl-2-[(2-prop-2-ynoxyacetyl)amino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C27H34N4O5S/c1-6-11-36-15-22(33)30-24(27(3,4)5)26(35)31-14-20(32)12-21(31)25(34)28-13-18-7-9-19(10-8-18)23-17(2)29-16-37-23/h1,7-10,16,20-21,24,32H,11-15H2,2-5H3,(H,28,34)(H,30,33)/t20-,21+,24-/m1/s1
• InChIKey: UGJHKPQUMUDIQJ-ZFGGDYGUSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCC#C)O

(S,R,S)-AHPC-Propargyl(CAT: I017618) is a derivative of the cereblon (CRBN) ligand that serves as a key component in the design of PROTACs (proteolysis-targeting chimeras). This molecule enables selective recruitment of CRBN, an E3 ubiquitin ligase, for the targeted degradation of specific proteins. The propargyl group provides a functional handle for conjugation with target ligands, facilitating the generation of customized PROTACs for various applications. (S,R,S)-AHPC-Propargyl is an essential tool in drug discovery and chemical biology research, particularly in exploring targeted protein degradation as a novel therapeutic strategy.