SRT 1720 Hydrochloride

• CAT Number: I000075
• CAS Number: 1001645-58-4
• Molecular Formula: C25H23N7OS • XHCl
• Molecular Weight: 506
• Purity: ≥95%
• Synonyms: N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;hydrochloride
• Target: Sirtuin
• Solubility: DMSO: 38 mg/mL, H2O: <1 mg/mL
• Storage: 3 years -20C powder
• IC50: 0.16 μM(EC1.5 for SIRT1)
• InChIKey: DTGRRMPPXCRRIM-UHFFFAOYSA-N

SRT1720 hydrochloride is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM；SIRT3: EC1.5 > 300 μM).IC50 Value: 0.16 μM(EC1.5 for SIRT1)Target: SIRT1SRT 1720 binds to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates. In diet-induced obese and genetically obese mice, SRT1720 improved insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity. Thus, SRT1720 is a promising new therapeutic agent for treating diseases of ageing such as type 2 diabetes.

Reference

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