For research use only. Not for therapeutic Use.
A small-molecule activator of the sirtuin subtype SIRT1; 1000x more potent than resveratrol. In animal studies it was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increased mitochondrial and metabolic function
| Catalog Number | I047574 |
| CAS Number | 2109175-23-5 |
| Molecular Formula | C25H23N7OS.4HCl |
| Purity | ≥95% |
| IUPAC Name | N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;tetrahydrochloride |
| InChI | InChI=1S/C25H23N7OS.4ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;;;;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);4*1H |
| SMILES | C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl.Cl.Cl.Cl |
| Reference | JC Milne et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007, 450(7170), 712–7160.
H Dai et al. SIRT1 activation by small molecules – kinetic and biophysical evidence for direct interaction of enzyme and activator. J. Biol. Chem. 2010, 285(43), 32695–32703.
E Callaway. GlaxoSmithKline strikes back over anti-ageing pills: Drugs do work as thought, says pharmaceutical giant. Nature 2010-08-16.
RK Minor et al. SRT1720 improves survival and healthspan of obese mice. Scientific Reports 2011, 1, 70. |
