For research use only. Not for therapeutic Use.
SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].
SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model[1].
| Catalog Number | I018083 |
| CAS Number | 2245942-72-5 |
| Synonyms | 5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy-1,2-oxazole-3-carboxamide |
| Molecular Formula | C13H11Cl2N3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H11Cl2N3O4/c14-9-2-1-7(5-10(9)15)12(19)16-4-3-8-6-11(18-22-8)13(20)17-21/h1-2,5-6,21H,3-4H2,(H,16,19)(H,17,20) |
| InChIKey | JFGOILLZIAIYGA-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1C(=O)NCCC2=CC(=NO2)C(=O)NO)Cl)Cl |
| Reference | [1]. Shen S, et al. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 4. |
