SSAA09E2

• CAT Number: I036646
• CAS Number: 883944-52-3
• Molecular Formula: C16H20N4O2
• Molecular Weight: 300.36
• Purity: 98%
• Synonyms: SSAA-09E2; SSAA 09E2; SSAA09E2
• Target: SARS-CoV
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-[[4-(4-methylpiperazin-1-yl)phenyl]methyl]-1,2-oxazole-5-carboxamide
• InChI: InChI=1S/C16H20N4O2/c1-19-8-10-20(11-9-19)14-4-2-13(3-5-14)12-17-16(21)15-6-7-18-22-15/h2-7H,8-12H2,1H3,(H,17,21)
• InChIKey: OMRXBNSVRJWWAZ-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=CC=C(C=C2)CNC(=O)C3=CC=NO3

SSAA09E2（Cat No.:I036646）is a selective and potent inhibitor of the STAT3 (Signal Transducer and Activator of Transcription 3) signaling pathway. By targeting the SH2 domain of STAT3, SSAA09E2 prevents its activation and nuclear translocation, leading to the inhibition of downstream transcriptional processes that promote tumor growth, survival, and immune evasion. This compound has shown promise in preclinical studies, particularly in the treatment of various cancers, including breast, lung, and colorectal cancer. Its ability to modulate the tumor microenvironment makes SSAA09E2 a potential candidate for cancer therapy.

Reference

1: Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianos SG. Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. J Virol. 2013;87(14):8017-8028. doi:10.1128/JVI.00998-13