SSR125543

• CAT Number: I009587
• CAS Number: 752253-39-7
• Molecular Formula: C27H28ClFN2OS
• Molecular Weight: 483.04
• Purity: ≥95%
• Synonyms: SSR125543; SSR-125543; SSR 125543; SSR125543A; SSR-125543A; SSR 125543A.;(S)-4-(2-chloro-4-methoxy-5-methylphenyl)-N-(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-(prop-2-yn-1-yl)thiazol-2-amine
• Target: CFTR
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine
• InChI: InChI=1S/C27H28ClFN2OS/c1-6-11-31(24(13-19-8-9-19)20-10-7-16(2)23(29)14-20)27-30-26(18(4)33-27)21-12-17(3)25(32-5)15-22(21)28/h1,7,10,12,14-15,19,24H,8-9,11,13H2,2-5H3/t24-/m0/s1
• InChIKey: IEAKXXNRGSLYTQ-DEOSSOPVSA-N
• SMILES: C#CCN([C@H](C1=CC=C(C)C(F)=C1)CC2CC2)C3=NC(C4=CC(C)=C(OC)C=C4Cl)=C(C)S3

SSR125543(CAT: I009587) is a potent, selective, and orally active antagonist of the corticotropin-releasing factor 1 (CRF1) receptor. By inhibiting CRF1, it modulates the hypothalamic-pituitary-adrenal (HPA) axis, reducing stress-induced hormonal and behavioral responses. This mechanism positions SSR125543 as a valuable tool in neuropsychological research, particularly for studying stress-related disorders such as anxiety, depression, and post-traumatic stress disorder (PTSD). Its high selectivity and oral bioavailability make it an important compound for exploring CRF1-targeted therapeutic strategies in preclinical and clinical settings.