For research use only. Not for therapeutic Use.
ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].
ST-1006 (10 μM) is a potent inducer of basophil migration and induces migration of basophils[2].
ST-1006 (0-100 μM) suppresses FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils[2].
ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) has anti-inflammatory effect and displays an antipruritic effect[1].
| Catalog Number | I036668 |
| CAS Number | 1196994-11-2 |
| Synonyms | 4-N-[(2,6-dichlorophenyl)methyl]-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine |
| Molecular Formula | C16H20Cl2N6 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H20Cl2N6/c1-23-5-7-24(8-6-23)15-9-14(21-16(19)22-15)20-10-11-12(17)3-2-4-13(11)18/h2-4,9H,5-8,10H2,1H3,(H3,19,20,21,22) |
| InChIKey | ICAQZJCLBRKWBG-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=NC(=NC(=C2)NCC3=C(C=CC=C3Cl)Cl)N |
| Reference | [1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397. [2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73. |
