For research use only. Not for therapeutic Use.
ST-193（Cat No.:I013668）is a small molecule inhibitor that targets the protein ADP-ribosyltransferase, particularly tankyrase, involved in the regulation of the Wnt/β-catenin signaling pathway. By inhibiting tankyrase, ST-193 disrupts the interaction between tankyrase and AXIN, leading to the stabilization of AXIN and the degradation of β-catenin, thereby downregulating Wnt signaling. This makes ST-193 a potential therapeutic agent for cancers driven by aberrant Wnt signaling, such as colorectal and other solid tumors. Additionally, ST-193 is being studied for its potential neuroprotective effects and as a tool in cancer therapy.
| Catalog Number | I013668 |
| CAS Number | 489416-12-8 |
| Molecular Formula | C₂₄H₂₅N₃O |
| Purity | ≥95% |
| Target | Arenavirus |
| Solubility | DMSO: ≥ 150 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 1-(4-methoxyphenyl)-N-[(4-propan-2-ylphenyl)methyl]benzimidazol-5-amine |
| InChI | InChI=1S/C24H25N3O/c1-17(2)19-6-4-18(5-7-19)15-25-20-8-13-24-23(14-20)26-16-27(24)21-9-11-22(28-3)12-10-21/h4-14,16-17,25H,15H2,1-3H3 |
| InChIKey | JPSZEXYTKSIPDW-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC=C(C=C1)CNC2=CC3=C(C=C2)N(C=N3)C4=CC=C(C=C4)OC |
| Reference | [1]. Burgeson JR, et al. Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett. 2013 Feb 1;23(3):750-6. <br>[2]. Larson RA, et al. Identification of a broad-spectrum arenavirus entry inhibitor. J Virol. 2008 Nov;82(21):10768-75.<br>[3]. Cashman KA, et al. Evaluation of Lassa antiviral compound ST-193 in a guinea pig model. Antiviral Res. 2011 Apr;90(1):70-9. |
