For research use only. Not for therapeutic Use.
Dopamine D3 receptor antagonist
| Catalog Number | I036672 |
| CAS Number | 854924-64-4 |
| Molecular Formula | C22H26N2O |
| Purity | ≥95% |
| IUPAC Name | (E)-N-[4-(3,4-dihydro-1H-isoquinolin-2-yl)butyl]-3-phenylprop-2-enamide |
| InChI | InChI=1S/C22H26N2O/c25-22(13-12-19-8-2-1-3-9-19)23-15-6-7-16-24-17-14-20-10-4-5-11-21(20)18-24/h1-5,8-13H,6-7,14-18H2,(H,23,25)/b13-12+ |
| SMILES | C1CN(CC2=CC=CC=C21)CCCCNC(=O)/C=C/C3=CC=CC=C3 |
| Reference | P Pyrko. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res. 2007, 67, 10920–8.
JJ Gills et al. Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo. Clin. Cancer Res. 2007, 13(17), 5183–5194.
WA Chow et al. Anti-HIV drugs for cancer therapeutics: back to the future?. Lancet Oncol. 2009, 10 (1), 61–71. |
