For research use only. Not for therapeutic Use.
ST074946 （Cat No.: I036667） is a potent and selective inhibitor targeting the enzyme Histone Deacetylase 6 (HDAC6), with an IC₅₀ of 4 nM. It shows high selectivity over other HDAC isoforms, making it valuable for studying HDAC6-specific biological pathways. HDAC6 plays a role in protein degradation, cell motility, and immune responses. ST074946 is commonly used in preclinical research related to cancer, neurodegenerative diseases, and inflammation. Its strong inhibitory activity and specificity make it an excellent tool for mechanistic and therapeutic studies.
| CAS Number | 185447-73-8 |
| Synonyms | ST074946; ST 074946; ST-074946. |
| Molecular Formula | C16H16N4O |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 3-amino-6,6-dimethyl-2-phenyl-8H-pyrano[4,5-e]pyridazine-4-carbonitrile |
| InChI | InChI=1S/C16H16N4O/c1-16(2)8-12-13(9-17)15(18)20(19-14(12)10-21-16)11-6-4-3-5-7-11/h3-8H,10,18H2,1-2H3 |
| InChIKey | XQJQZTOXHGIQCA-UHFFFAOYSA-N |
| SMILES | N#CC1=C(N)N(C2=CC=CC=C2)N=C3C1=CC(C)(C)OC3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
