STA-21

• CAT Number: I009596
• CAS Number: 111540-00-2
• Molecular Formula: C19H14O4
• Molecular Weight: 306.317
• Purity: ≥95%
• Synonyms: STA21; STA 21; STA21; Ochromycinone; NSC 628869.;8-hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione
• Target: STAT
• Solubility: Soluble in DMSO, not in water
• Storage: Store at -20°C
• IUPAC Name: 8-hydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione
• InChI: InChI=1S/C19H14O4/c1-9-7-10-5-6-12-17(15(10)14(21)8-9)19(23)11-3-2-4-13(20)16(11)18(12)22/h2-6,9,20H,7-8H2,1H3
• InChIKey: ZAWXOCUFQSQDJS-UHFFFAOYSA-N
• SMILES: CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O

Ochromycinone (Cat No.:I009596) is a naturally occurring antibiotic and a potent inhibitor of STAT3. It can inhibit STAT3 DNA binding activity and STAT3 dimerization. Ochromycinone exhibits both anticancer and antibacterial activities, making it a promising compound for therapeutic use.

Reference

1:STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis. Ahmad SF, Ansari MA, Nadeem A, Zoheir KM, Bakheet SA, Alsaad AM, Al-Shabanah OA, Attia SM.Immunobiology. 2017 Feb;222(2):206-217. doi: 10.1016/j.imbio.2016.10.001. Epub 2016 Oct 3. PMID: 27717524 2:STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis. Park JS, Kwok SK, Lim MA, Kim EK, Ryu JG, Kim SM, Oh HJ, Ju JH, Park SH, Kim HY, Cho ML.Arthritis Rheumatol. 2014 Apr;66(4):918-29. doi: 10.1002/art.38305. PMID: 24757144 Free Article3:Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor. Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, DiGiovanni J, Sano S.J Invest Dermatol. 2011 Jan;131(1):108-17. doi: 10.1038/jid.2010.255. Epub 2010 Sep 2. PMID: 20811392 Free Article