STA-21

• CAT Number: I009596
• CAS Number: 111540-00-2
• Molecular Formula: C19H14O4
• Molecular Weight: 306.32
• Purity: ≥95%
• Synonyms: STA21; STA 21; STA21; Ochromycinone; NSC 628869.;8-hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione
• Target: Stem Cell/Wnt
• Solubility: Soluble in DMSO, not in water
• Storage: Store at -20°C
• IUPAC Name: 8-hydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione
• InChI: InChI=1S/C19H14O4/c1-9-7-10-5-6-12-17(15(10)14(21)8-9)19(23)11-3-2-4-13(20)16(11)18(12)22/h2-6,9,20H,7-8H2,1H3
• InChIKey: ZAWXOCUFQSQDJS-UHFFFAOYSA-N
• SMILES: CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O

STA-21 (Cat No.:I009596) is a selective inhibitor of the heat shock protein 90 (HSP90) chaperone complex, which plays a critical role in protein folding and stabilization. By targeting HSP90, STA-21 disrupts the function of numerous client proteins involved in cancer cell survival and proliferation. Its mechanism makes it a promising candidate for cancer therapy, particularly in tumors where HSP90 is overexpressed. STA-21’s ability to inhibit cancer progression via the modulation of protein folding pathways provides valuable insight for targeted therapies.