For research use only. Not for therapeutic Use.
Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members[1].
Stafia-1 shows at least 9-fold selectivity over STAT5b and higher selectivity against other STAT family members[1].
| Catalog Number | I045826 |
| CAS Number | 2582757-90-0 |
| Synonyms | [3,5-bis(3,4,5-trimethoxyphenyl)phenyl] dihydrogen phosphate |
| Molecular Formula | C24H27O10P |
| Purity | ≥95% |
| InChI | InChI=1S/C24H27O10P/c1-28-19-10-16(11-20(29-2)23(19)32-5)14-7-15(9-18(8-14)34-35(25,26)27)17-12-21(30-3)24(33-6)22(13-17)31-4/h7-13H,1-6H3,(H2,25,26,27) |
| InChIKey | UGUOUFLCZFMHNI-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OC)OC)C2=CC(=CC(=C2)OP(=O)(O)O)C3=CC(=C(C(=C3)OC)OC)OC |
| Reference | [1]. Natarajan K, et al. Stafia-1: a STAT5a-Selective Inhibitor Developed via Docking-Based Screening of in Silico O-Phosphorylated Fragments. Chemistry. 2020;26(1):148-154. |
