For research use only. Not for therapeutic Use.
Stat3 Inhibitor I (Cat.No:I003766), also known as S3I-201 (CAS 501919-59-1), is a small molecule inhibitor of signal transducer and activator of transcription 3 (Stat3). Stat3 is involved in cell growth, survival, and immune responses, making it an attractive target in cancer therapy. S3I-201 has shown promise in preclinical studies as an anticancer agent with potential therapeutic applications.
| Catalog Number | I003766 |
| CAS Number | 501919-59-1 |
| Synonyms | 2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid |
| Molecular Formula | C₁₆H₁₅NO₇S |
| Purity | ≥95% |
| Target | STAT |
| Solubility | DMSO: ≤ 25 mg/mL |
| Storage | 3 years -20℃ powder |
| IC50 | 86 uM |
| IUPAC Name | 2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid |
| InChI | InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21) |
| InChIKey | HWNUSGNZBAISFM-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O |
| Reference | 1:NSC 74859 enhances doxorubicin cytotoxicity via inhibition of epithelial-mesenchymal transition in hepatocellular carcinoma cells. Hu QD, Chen W, Yan TL, Ma T, Chen CL, Liang C, Zhang Q, Xia XF, Liu H, Zhi X, Zheng XX, Bai XL, Yu XZ, Liang TB.Cancer Lett. 2012 Dec 28;325(2):207-13. doi: 10.1016/j.canlet.2012.07.003. Epub 2012 Jul 7. PMID: 22781398 <br /> |
