For research use only. Not for therapeutic Use.
STAT5-IN-2 ( Cat No. : I019553 ) is a STAT5 inhibitor with EC50 values of 9 μM and 5 μM in K562 and KU812 cells, respectively. STAT5-IN-2 has high anti-leukemia activity. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| Catalog Number | I019553 |
| CAS Number | 2111834-61-6 |
| Molecular Formula | C₂₆H₂₇N₃O |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 1-[2-(1H-indol-5-yloxy)ethyl]-4,4-dimethyl-6-pyridin-3-yl-2,3-dihydroquinoline |
| InChI | InChI=1S/C26H27N3O/c1-26(2)10-13-29(14-15-30-22-6-7-24-20(16-22)9-12-28-24)25-8-5-19(17-23(25)26)21-4-3-11-27-18-21/h3-9,11-12,16-18,28H,10,13-15H2,1-2H3 |
| InChIKey | BELIZDRKUICBJC-UHFFFAOYSA-N |
| SMILES | CC1(CCN(C2=C1C=C(C=C2)C3=CN=CC=C3)CCOC4=CC5=C(C=C4)NC=C5)C |
| Reference | [1]. Ludovic Juen, et al. New Inhibitor Targeting Signal Transducer and Activator of Transcription 5 (STAT5) Signaling in Myeloid Leukemias. J Med Chem. 2017 Jul 27;60(14):6119-6136. |
