For research use only. Not for therapeutic Use.
STAT6-IN-3(CAT: I040902) is a selective inhibitor of STAT6 (Signal Transducer and Activator of Transcription 6), a transcription factor that plays a crucial role in immune response, particularly in the regulation of Th2 cell differentiation and cytokine production. STAT6 is implicated in the pathogenesis of allergic diseases, asthma, and certain cancers, where it mediates the effects of interleukin-4 (IL-4) and interleukin-13 (IL-13). By inhibiting STAT6, STAT6-IN-3 can block these pro-inflammatory signaling pathways, offering potential therapeutic benefits in inflammatory and autoimmune disorders. This compound is highly relevant for Inflammation & Immunology Research, especially in the development of treatments for allergic conditions and Th2-mediated diseases.
| CAS Number | 371919-80-1 |
| Synonyms | [4-[(E)-3-[[(2S)-1-[(2S)-2-[(4-iodophenyl)-phenylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxoprop-1-enyl]phenyl] dihydrogen phosphate |
| Molecular Formula | C32H35IN3O7P |
| Purity | ≥95% |
| IUPAC Name | [4-[(E)-3-[[(2S)-1-[(2S)-2-[(4-iodophenyl)-phenylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxoprop-1-enyl]phenyl] dihydrogen phosphate |
| InChI | InChI=1S/C32H35IN3O7P/c1-32(2,3)29(34-28(37)20-13-22-11-18-26(19-12-22)43-44(40,41)42)31(39)35-21-7-10-27(35)30(38)36(24-8-5-4-6-9-24)25-16-14-23(33)15-17-25/h4-6,8-9,11-20,27,29H,7,10,21H2,1-3H3,(H,34,37)(H2,40,41,42)/b20-13+/t27-,29+/m0/s1 |
| InChIKey | BKWLAOMTDOHPQG-WTUSEGCYSA-N |
| SMILES | CC(C)(C)C(C(=O)N1CCCC1C(=O)N(C2=CC=CC=C2)C3=CC=C(C=C3)I)NC(=O)C=CC4=CC=C(C=C4)OP(=O)(O)O |
