For research use only. Not for therapeutic Use.
Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands[1].
Stepronin (0.1-100 µM; 20 min) induces significant reductions in ISOP(Isoproterenol)-evoked SCC (short circuit current) value in a dose-dependent manner in canine tracheal epithelium[1].
Stepronin (10-100 µM; 20 min) significantly inhibits the basal secretion and ISOP-evoked PD (potential difference) value in a dose-dependent manner in canine tracheal epithelium[1].
Stepronin (100 µM; 20 min) significantly inhibits ISOP-induced [3H]-glycoconjugate secretion in submucosal glands[1].
| Catalog Number | I009598 |
| CAS Number | 72324-18-6 |
| Synonyms | 2-[2-(thiophene-2-carbonylsulfanyl)propanoylamino]acetic acid |
| Molecular Formula | C10H11NO4S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H11NO4S2/c1-6(9(14)11-5-8(12)13)17-10(15)7-3-2-4-16-7/h2-4,6H,5H2,1H3,(H,11,14)(H,12,13) |
| InChIKey | JNYSEDHQJCOWQU-UHFFFAOYSA-N |
| SMILES | CC(C(=O)NCC(=O)O)SC(=O)C1=CC=CS1 |
| Reference | [1]. Yamada K, et al. An expectorant, stepronin, reduces airway secretion in vitro. Respiration. 1994;61(1):42-7. |
