For research use only. Not for therapeutic Use.
Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM[1].
Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plant Sterculia foetida with numerous biological activities[2].Sterculic acid is able to reduce adrenomedullin expression (AP, RP, APS, IML, in preparation)[2].Sterculic acid is also able to mediate anti-inflammatory and protective effects[2].Sterculic acid has a potent luteolytic effect in ovines by inhibition in the synthesis of progesterone, which causes luteal regression[2].
Sterculic acid has been proposed as a potential tool for the treatment of metabolic syndrome (MS) since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1)
in vivo[3].
| Catalog Number | I044337 |
| CAS Number | 738-87-4 |
| Synonyms | 8-(2-octylcyclopropen-1-yl)octanoic acid |
| Molecular Formula | C19H34O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H34O2/c1-2-3-4-5-7-10-13-17-16-18(17)14-11-8-6-9-12-15-19(20)21/h2-16H2,1H3,(H,20,21) |
| InChIKey | PQRKPYLNZGDCFH-UHFFFAOYSA-N |
| SMILES | CCCCCCCCC1=C(C1)CCCCCCCC(=O)O |
| Reference | [1]. Lei Zhang, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76. [2]. Rafael Peláez, et al. Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases. Cells. 2020 Jan 7;9(1):140. [3]. Abril Ramírez-Higuera, et al. Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model. J Med Food. 2020 Mar;23(3):305-311. |
