For research use only. Not for therapeutic Use.
Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities[1][2].
Stevioside (10 μM, 24-48 h) can enhance cytotoxicity of 5-Fluorouracil (5-Fu, HY-90006) to MDA-MB-231 and SKBR3cells[1].
Stevioside (10 μM, 48 h) combinated with 5-Fu (HY-90006) could increase the ratio of Bax to Bcl-2 in MDA-MB-231 cells, thereby triggering apoptosis[1].
Stevioside (10-1000 μM, 6 h) induces TNF-α and IL-1β release in THP-1 cells[2].
Stevioside (20 mg/kg, p.o., daily, 10 days) prevents significant increase in glycaemia in NMRI Haan mice[3].
Stevioside (50-200 mg/kg, i.v., one time) reduces blood pressure in a dose-dependent manner in spontaneously hypertensive rats[4].
Stevioside (6.25-25 mg/kg, p.o., daily, 15 days) increases the proliferative response of in LPS stimulated B-lymphocytes in Balb/c mice[5].
| Catalog Number | R058193 |
| CAS Number | 57817-89-7 |
| Synonyms | [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate |
| Molecular Formula | C38H60O18 |
| Purity | ≥95% |
| InChI | InChI=1S/C38H60O18/c1-16-11-37-9-5-20-35(2,7-4-8-36(20,3)34(50)55-32-29(49)26(46)23(43)18(13-40)52-32)21(37)6-10-38(16,15-37)56-33-30(27(47)24(44)19(14-41)53-33)54-31-28(48)25(45)22(42)17(12-39)51-31/h17-33,39-49H,1,4-15H2,2-3H3/t17-,18-,19-,20+,21+,22-,23-,24-,25+,26+,27+,28-,29-,30-,31+,32+,33+,35-,36-,37-,38+/m1/s1 |
| InChIKey | UEDUENGHJMELGK-HYDKPPNVSA-N |
| SMILES | CC12CCCC(C1CCC34C2CCC(C3)(C(=C)C4)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)(C)C(=O)OC7C(C(C(C(O7)CO)O)O)O |
| Reference | [1]. Khare N, et al. Stevioside mediated chemosensitization studies and cytotoxicity assay on breast cancer cell lines MDA-MB-231 and SKBR3. Saudi J Biol Sci. 2019 Nov;26(7):1596-1601. [2]. Boonkaewwan C, Toskulkao C, Vongsakul M. Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. J Agric Food Chem. 2006 Feb 8;54(3):785-9. [3]. Ilić V, Vukmirović S, Stilinović N, Čapo I, Arsenović M, Milijašević B. Insight into anti-diabetic effect of low dose of stevioside. Biomed Pharmacother. 2017 Jun;90:216-221. [4]. Chan P, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci. [5]. Sehar I, Kaul A, Bani S, Pal HC, Saxena AK. Immune up regulatory response of a non-caloric natural sweetener, stevioside. Chem Biol Interact. 2008 May 28;173(2):115-21. |
