STF-083010

• CAT Number: I003089
• CAS Number: 307543-71-1
• Molecular Formula: C15H11NO3S2
• Molecular Weight: 317.41
• Purity: ≥95%
• Synonyms: (Z)-N-((2-oxonaphthalen-1(2H)-ylidene)methyl)thiophene-2-sulfonamide
• Target: IRE1
• Solubility: DMSO 5 mg/ml
• Storage: Store at -20C
• IUPAC Name: (NE)-N-[(2-hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide
• InChI: InChI=1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
• InChIKey: TVIVJHZHPKNDAQ-MHWRWJLKSA-N
• SMILES: C1=CC=C2C(=C1)C=CC(=C2/C=N/S(=O)(=O)C3=CC=CS3)O

STF-083010(CAT: I003089) is a novel small-molecule inhibitor of Ire1α, specifically targeting its endonuclease activity while sparing its kinase function. By inhibiting Ire1α-mediated splicing of XBP1 mRNA, it disrupts the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. This compound is particularly valuable in cellular stress and oncology research, where the UPR plays a critical role in tumor survival and adaptation to stress. STF-083010 provides a precise tool for studying ER stress signaling pathways and exploring therapeutic strategies targeting the UPR in cancer and other diseases characterized by proteostasis dysregulation.