STF-118804

• CAT Number: I005352
• CAS Number: 894187-61-2
• Molecular Formula: C25H23N3O4S
• Molecular Weight: 461.54
• Purity: ≥95%
• Synonyms: 4-[5-methyl-4-[(4-methylphenyl)sulfonylmethyl]-1,3-oxazol-2-yl]-N-(pyridin-3-ylmethyl)benzamide
• Target: Apoptosis
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at -20C
• InChI: InChI=1S/C25H23N3O4S/c1-17-5-11-22(12-6-17)33(30,31)16-23-18(2)32-25(28-23)21-9-7-20(8-10-21)24(29)27-15-19-4-3-13-26-14-19/h3-14H,15-16H2,1-2H3,(H,27,29)
• InChIKey: DLFCEZOMHBPDGI-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)CC2=C(OC(=N2)C3=CC=C(C=C3)C(=O)NCC4=CN=CC=C4)C

STF-118804（Cat No.:I005352）is a selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme critical in NAD+ biosynthesis. By blocking NAMPT, STF-118804 effectively depletes NAD+ levels, impairing energy production in cancer cells that heavily rely on NAD+ for growth and survival. This targeted inhibition triggers apoptosis in NAD+-dependent tumor cells, making STF-118804 a promising compound in cancer research, particularly for hematologic malignancies. Its specificity for NAMPT provides a unique approach to targeting cancer cell metabolism, offering potential for developing therapies against tumors with elevated metabolic demands.

Reference

[1]. Matheny CJ, et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21;20(11):1352-63.