Stibogluconate sodium

• CAT Number: I002038
• CAS Number: 16037-91-5
• Molecular Formula: C12H17O17Sb2 • 3Na [9H2O]
• Molecular Weight: 907.90
• Purity: ≥95%
• Synonyms: Antimony Sodium Gluconate
• Target: target: SHP-1, SHP-2, PTP1B.
• Storage: -20°C
• IUPAC Name: trisodium;(4R,5S,6R)-2-[[(4R,5S,6R)-4-carboxylato-6-[(1R)-1,2-dihydroxyethyl]-5-hydroxy-2-oxo-1,3,2lambda5-dioxastibinan-2-yl]oxy]-6-[(1R)-1,2-dihydroxyethyl]-5-hydroxy-2-oxo-1,3,2lambda5-dioxastibinane-4-carboxylate;nonahydrate
• InChI: InChI=1S/2C6H10O7.3Na.9H2O.3O.2Sb/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h2*2-5,7-8,10H,1H2,(H,12,13);;;;9*1H2;;;;;/q2*-2;3*+1;;;;;;;;;;;;;2*+2/p-2/t2*2-,3-,4+,5-;;;;;;;;;;;;;;;;;/m11................./s1
• InChIKey: CUEDNFKBTFCOSV-UZVLBLASSA-L
• SMILES: C([C@H]([C@@H]1[C@@H]([C@@H](O[Sb](=O)(O1)O[Sb]2(=O)O[C@@H]([C@@H]([C@@H](O2)C(=O)[O-])O)[C@@H](CO)O)C(=O)[O-])O)O)O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+]

Stibogluconate sodium（Cat No.:I002038）is an antimonial drug primarily used to treat leishmaniasis, a parasitic disease transmitted by sandflies. It acts by inhibiting key enzymes in the parasite, disrupting its energy metabolism and leading to cell death. Stibogluconate sodium is particularly effective against cutaneous and visceral leishmaniasis, making it an essential treatment option in endemic regions. Administered via injection, it has a unique mechanism of action that targets parasite-specific pathways, though side effects may occur, requiring careful monitoring. Its effectiveness and unique action make it valuable in neglected tropical disease treatment.

Reference

[1]. Pathak MK et al. Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol. 2001 Sep 15;167(6):3391-7.
[2]. Keke Fan et al. Sodium Stibogluconate Interacts with IL-2 in Anti-Renca Tumor Action via a T Cell-Dependent Mechanism in Connection with Induction of Tumor-Infiltrating Macrophages. The journal of immunology. 2016 Sep 27.