STING agonist-1

• CAT Number: I004635
• CAS Number: 702662-50-8
• Molecular Formula: C21H16ClFN2O3S
• Molecular Weight: 430.90
• Purity: ≥95%
• Synonyms: 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide
• Target: VEEV, STING
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 24.57 μM (IC90)
• IUPAC Name: 4-[(2-chloro-6-fluorophenyl)methyl]-N-(furan-2-ylmethyl)-3-oxo-1,4-benzothiazine-6-carboxamide
• InChIKey: NAGKYJATVFXZKN-UHFFFAOYSA-N
• SMILES: C1C(=O)N(C2=C(S1)C=CC(=C2)C(=O)NCC3=CC=CO3)CC4=C(C=CC=C4Cl)F

STING agonist-1 (G10) is a ynthetic compound that activates the stimulator of interferon genes (STING) pathway, which plays a crucial role in the innate immune response. By stimulating STING, it induces the production of type I interferons and other pro-inflammatory cytokines, enhancing immune surveillance and anti-tumor activity. STING Agonist-1 is being investigated in cancer immunotherapy and infectious diseases for its potential to activate the immune system and improve therapeutic outcomes through enhanced immune activation.