STING agonist-26

• CAT Number: I041726
• CAS Number: 2868261-48-5
• Molecular Formula: C40H49N15O5
• Molecular Weight: 819.91
• Purity: ≥95%
• Synonyms: 3-[(E)-4-[5-carbamoyl-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-(3-piperazin-1-ylpropoxy)benzimidazol-1-yl]but-2-enyl]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]imidazo[4,5-b]pyridine-6-carboxamide
• InChI: InChI=1S/C40H49N15O5/c1-5-54-30(18-24(3)49-54)37(58)47-39-45-28-20-26(34(41)56)22-32(60-17-9-12-51-15-10-43-11-16-51)33(28)52(39)13-7-8-14-53-36-29(21-27(23-44-36)35(42)57)46-40(53)48-38(59)31-19-25(4)50-55(31)6-2/h7-8,18-23,43H,5-6,9-17H2,1-4H3,(H2,41,56)(H2,42,57)(H,45,47,58)(H,46,48,59)/b8-7+
• InChIKey: KEKANDJOQLPZHH-BQYQJAHWSA-N
• SMILES: CCN1C(=CC(=N1)C)C(=O)NC2=NC3=C(N2CC=CCN4C5=C(C=C(C=N5)C(=O)N)N=C4NC(=O)C6=CC(=NN6CC)C)C(=CC(=C3)C(=O)N)OCCCN7CCNCC7

STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].
STING agonist-26 (10 μM; 3 h or 5 h) increases the level of phosphorylated STING, TBK1 and IRF3 following 3-h incubation, increases the level of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15 following 5-h incubation, and CCL-5, in THP-1 cells[1].
STING agonist-26 adjuvant (20?μg STING agonist-26 and 5 μg RBD-Fc per mouse; im; 3 times at 14-day intervals) induces strong antibody immune response induced by the SARS-CoV-2 RBD-Fc protein in mice model[1].

Reference

[1]. Liu Z, et al. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs. Cell Res. 2022 Mar;32(3):269-287.
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