STING agonist-7

• CAT Number: I044071
• CAS Number: 2767442-46-4
• Molecular Formula: C17H12N4O4
• Molecular Weight: 336.30
• Purity: ≥95%
• Synonyms: 2-[(pyrazolo[1,5-a]pyrimidine-3-carbonylamino)methyl]-1-benzofuran-7-carboxylic acid
• InChI: InChI=1S/C17H12N4O4/c22-16(13-9-20-21-6-2-5-18-15(13)21)19-8-11-7-10-3-1-4-12(17(23)24)14(10)25-11/h1-7,9H,8H2,(H,19,22)(H,23,24)
• InChIKey: BICDHWPHEXMVAT-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=C1)C(=O)O)OC(=C2)CNC(=O)C3=C4N=CC=CN4N=C3

STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly[1].
STING agonist-7 (compound 11) is active in biochemical assays but inactive in cellular reporter assays[1].

Reference

[1]. Emily C Cherney, et al. Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization. J Med Chem. 2022 Feb 24;65(4):3518-3538.
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