STING-IN-2

• CAT Number: I036719
• CAS Number: 346691-38-1
• Molecular Formula: C15H16N2O4
• Molecular Weight: 288.30
• Purity: ≥95%
• Synonyms: N-(4-butylphenyl)-5-nitrofuran-2-carboxamide
• InChI: InChI=1S/C15H16N2O4/c1-2-3-4-11-5-7-12(8-6-11)16-15(18)13-9-10-14(21-13)17(19)20/h5-10H,2-4H2,1H3,(H,16,18)
• InChIKey: QMVOHFICEFYHMK-UHFFFAOYSA-N
• SMILES: CCCCC1=CC=C(C=C1)NC(=O)C2=CC=C(O2)[N+](=O)[O-]

STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research[1].
THP-1 cells are pretreated with STING-IN-2 (C-170; 0.5 μM) and stimulated with cGAMP. STING-IN-2 (C-170) treatment decreases the IFNB1 and TNF mRNA levels, and also reduces the p-TBK1 levels[1].

Reference

[1]. Simone M Haag, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.
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