STING-IN-3

• CAT Number: I023909
• CAS Number: 2244881-69-2
• Molecular Formula: C17H20N2O4
• Molecular Weight: 316.35
• Purity: ≥95%
• Synonyms: N-(4-hexylphenyl)-5-nitrofuran-2-carboxamide
• InChI: InChI=1S/C17H20N2O4/c1-2-3-4-5-6-13-7-9-14(10-8-13)18-17(20)15-11-12-16(23-15)19(21)22/h7-12H,2-6H2,1H3,(H,18,20)
• InChIKey: WZVGWJZGQFSRBG-UHFFFAOYSA-N
• SMILES: CCCCCCC1=CC=C(C=C1)NC(=O)C2=CC=C(O2)[N+](=O)[O-]

STING-IN-3 is an inhibitor of stimulator of interferon genes (STING). STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING[1].
STING-IN-3 (0.02-2 μM) inhibits hsSTING and mmSTING, mediated IFNβ reporter activity in HEK293 cells[1].

Reference

[1]. Haag SM, et, al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.
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