STING-IN-7

• CAT Number: I040552
• CAS Number: 899947-07-0
• Molecular Formula: C16H14ClN3O
• Molecular Weight: 299.75
• Purity: ≥95%
• Synonyms: 1-(3-chloro-4-methylphenyl)-3-(1H-indol-3-yl)urea
• InChI: InChI=1S/C16H14ClN3O/c1-10-6-7-11(8-13(10)17)19-16(21)20-15-9-18-14-5-3-2-4-12(14)15/h2-9,18H,1H3,(H2,19,20,21)
• InChIKey: FWAWUBPOSFYSMU-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32)Cl

STING-IN-7 (Cat No.: I040552) is a selective small-molecule STING (Stimulator of Interferon Genes) inhibitor, designed to modulate innate immune responses. STING is a key adaptor protein in the cytosolic DNA-sensing pathway, triggering type I interferon production and inflammatory signaling. By inhibiting STING, STING-IN-7 helps prevent excessive immune activation, making it a potential therapeutic candidate for autoimmune and inflammatory diseases, such as systemic lupus erythematosus (SLE) and interferonopathies. It is used in preclinical research to explore immune regulation and inflammatory disease intervention strategies.

Reference

[1]. Po-Wei Chang, et al. Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors. Bioorg Med Chem. 2023 Oct 14:95:117502.
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