For research use only. Not for therapeutic Use.
STING-IN-7 (compound 21) is a potent STING inhibitor with an IC50 of 11.5 nM. STING-IN-7 inhibits the phosphorylation of STING and interferon regulatory factor 3 (IRF3)[1].
| Catalog Number | I040552 |
| CAS Number | 899947-07-0 |
| Synonyms | 1-(3-chloro-4-methylphenyl)-3-(1H-indol-3-yl)urea |
| Molecular Formula | C16H14ClN3O |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14ClN3O/c1-10-6-7-11(8-13(10)17)19-16(21)20-15-9-18-14-5-3-2-4-12(14)15/h2-9,18H,1H3,(H2,19,20,21) |
| InChIKey | FWAWUBPOSFYSMU-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32)Cl |
| Reference | [1]. Po-Wei Chang, et al. Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors. Bioorg Med Chem. 2023 Oct 14:95:117502. |
