STING ligand-1

• CAT Number: I019465
• CAS Number: 2365039-41-2
• Molecular Formula: C29H27ClFNO5
• Molecular Weight: 523.98
• Purity: ≥95%
• Synonyms: 2-[(3S,4S)-2-(4-tert-butyl-3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1-oxo-3,4-dihydroisoquinolin-4-yl]acetic acid
• InChI: InChI=1S/C29H27ClFNO5/c1-29(2,3)22-8-6-18(14-23(22)30)32-27(16-4-9-24-25(12-16)37-11-10-36-24)20(15-26(33)34)19-7-5-17(31)13-21(19)28(32)35/h4-9,12-14,20,27H,10-11,15H2,1-3H3,(H,33,34)/t20-,27+/m0/s1
• InChIKey: JAIAHSWXASHNQH-CCLHPLFOSA-N
• SMILES: CC(C)(C)C1=C(C=C(C=C1)N2C(C(C3=C(C2=O)C=C(C=C3)F)CC(=O)O)C4=CC5=C(C=C4)OCCO5)Cl

STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING[1].
STING ligand-1 (Compound 18) exhibits functional inhibition of STING mediated cytokine release[1].

Reference

[1]. Siu T, et al. Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING. ACS Med Chem Lett. 2018 Dec 6;10(1):92-97.
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