For research use only. Not for therapeutic Use.
STK683963(CAT: I036726) is a novel activator of ATG4B, a key cysteine protease involved in autophagy. By enhancing ATG4B activity, it promotes the maturation of autophagosomes, facilitating the autophagic degradation of damaged cellular components. This makes STK683963 a valuable tool for studying the regulation of autophagy and its therapeutic potential. It is particularly significant in oncology research, where modulating autophagy can influence tumor survival and response to therapy. With its targeted mechanism, STK683963 provides researchers with a precise means to explore autophagy-related pathways and develop innovative strategies for treating cancer and other diseases involving impaired autophagic processes.
| CAS Number | 370073-65-7 |
| Synonyms | STK-683963; STK 683963; STK683963 |
| Molecular Formula | C12H8FN3O2S |
| Purity | 98% |
| Target | Atg4 |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-((4-Fluorophenyl)amino)thiazolo[4,5-b]pyridine-5,7-diol |
| InChI | InChI=1S/C12H8FN3O2S/c13-6-1-3-7(4-2-6)14-12-16-11-10(19-12)8(17)5-9(18)15-11/h1-5H,(H3,14,15,16,17,18) |
| InChIKey | JBBNLKMLYZFWTN-UHFFFAOYSA-N |
| SMILES | OC1=CC(O)=C(SC(NC2=CC=C(F)C=C2)=N3)C3=N1 |
