STL427944

• CAT Number: I047716
• CAS Number: 292028-62-7
• Molecular Formula: C25H23N7O4
• Molecular Weight: 485.49
• Purity: ≥95%
• IUPAC Name: [3-[(E)-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)hydrazinylidene]methyl]phenyl] furan-2-carboxylate
• InChI: InChI=1S/C25H23N7O4/c33-22(21-10-5-13-35-21)36-20-9-4-6-18(16-20)17-26-31-24-28-23(27-19-7-2-1-3-8-19)29-25(30-24)32-11-14-34-15-12-32/h1-10,13,16-17H,11-12,14-15H2,(H2,27,28,29,30,31)/b26-17+
• SMILES: C1COCCN1C2=NC(=NC(=N2)N/N=C/C3=CC(=CC=C3)OC(=O)C4=CC=CO4)NC5=CC=CC=C5

STL427944 is FOXM1 inhibitor which selectively suppresses FOXM1 by inducing the relocalization of nuclear FOXM1 protein to the cytoplasm and promoting its subsequent degradation by autophagosomes. STL427944 suppresses FOXM1 activity in a variety of human cancer cell lines.
Keywords: STL427944 | Supplier | FOXM1 inhibitor | STL 427944 | STL-427944 | CAS [292028-62-7] | DNA-RNA | FOXM1 | Inhibitor | Transcription Factors | Chemoresistance

Reference

MS Chesnokov et al. Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells. Cell Death Dis. 2021 Jul 14;12(7):704.