Streptavidin

For research use only. Not for therapeutic Use.

  • CAT Number: I044225
  • CAS Number: 9013-20-1
  • Purity: ≥95%
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Streptavidin is a ∼60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ∼ 0.01 pM[1]. Streptavidin has an immunosuppressive role[2].
Streptavidin (2-200 μg/mL) significantly suppresses the proliferation of Lewis T cells to WF by 76%-83% compared with untreated responders[1].
Streptavidin (8-80 mg/kg) treatment is effective in prolonging rat cardiac allografts in the high-responder WF-to-Lewis combination[2].


Catalog Number I044225
CAS Number 9013-20-1
Purity ≥95%
Reference

[1]. Keleabetswe L. Mpye , et al. The effects of temperature on streptavidin-biotin binding using affinity isothermal titration calorimetry. AIMS Biophysics. 2020, 7(4): 236-247.

[2]. P Witkowski, et al. Effect of streptavidin on cardiac allograft prolongation is due to host T-Cell suppression. Transplant Proc. Jan-Feb 2005;37(1):116-8.
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